Mu-opioid receptor agonists are current mainstays of pain management. But the therapeutic use of these narcotic drugs is associated with serious side effects, including potentially deadly respiratory depression. So the best kratom for chronic pain, offers patients a natural opioid analgesic alternative which is much safer and works just as well as opioid pain pills
Kratom is a natural and unusual class of opioid receptor modulator with a distinct mechanism of analgesic action.
Researchers at the national pain management journal found that alkaloids including mitragynine and 7-hydroxymitragynine found in maeng da Kratom, are partial agonists of the human mu-opioid receptor and competitive antagonists at the kappa- and delta-opioid receptors.
But mitragynine and 7-hydroxymitragynine are also G-protein-biased agonists of the mu-opioid receptor, which do not recruit β-arrestin following receptor activation.
Which means that Kratom provides the natural holistic based pain relief as helpful as prescription opioid medication. But without the potentially lethal side effect of respiratory depression
Most effective green maeng da Kratom strains have a general, optimal dose for its therapeutic value, and for its ‘feel-good’ effects. Anything above this ideal dosage can have unpleasant effects.
And most people find that Kratom works more effectively when consumed on an empty stomach. Taken with a meal could nullify or dramatically reduce its effects.
The traditional method of using Kratom in Southeast Asia was using fresh leaves, removing stems and veins, bundling the leaves, and chewing the leaves.
The “toss ‘n’ wash” method of dosing Kratom is chasing the powder with water. Not recommended.
Kratom tea is a common method of using it. Simmer powdered Kratom in water for 20 minutes and drink the tea. Easier to drink, but if you strain out the soggy Kratom powder before drinking, you’ll lose some of the valuable, medicinal value of the plant.
Adding lemon juice to your Kratom tea can increase the bioavailability of its alkaloid content.
You can also mix measured Kratom powder with yogurt, applesauce, juice, peanut butter or chocolate milk.
My preferred method is making capsules of Kratom powder. It’s convenient, eliminates the unpleasant taste, and provides the desired therapeutic benefit within 20 minutes of swallowing the capsules.
Leaf alkaloid content varies from plant to plant, and from strain to strain. The most popular strains for pain relief both red and green veined versions are:
- Maeng Da
Red vein versions of the above Kratom strains tend to be more reliable for pain relief. And the general consensus is that Maeng Da is most potent of all.
Most strains of Kratom can help depression and anxiety. But differences in strain can change the type of experience you’ll have.
In general, the following red and green strains will help lift mood at higher dosages. And lower dosages of the same strains may be somewhat stimulating.
You can also buy water-based extracts of Kratom. These extracts have more alkaloid content than regular Kratom. One option is adding some extract to regular Kratom to potentiate its pain-relieving effects.